416: Kubaba
Sumerian King and the Only Female Listed on the Sumerian King’s List
Lived and Died: c. 25th Century BCE, Kish, Sumer (Present-day Iraq)
Other Translations: Kug-Baba or Kubau
The list claims she ruled for one hundred years around the Dynastic III Period of Sumerian History.
It is said she was originally a tavern keeper before rising up and becoming king—ruling in a time of peace and prosperity for her people.
Kubaba may have been the first woman ruler in known history.
In later times she was worshipped as a goddess and as a goddess her cult began in Carchemish (an ancient Sumerian city) before her popularity spread Westward and Northward to become a major goddess in the Neo-Hittite States.
It should be noted that some sources state the historical figure and the goddess do not represent the same person, and simply share a similar name.
Sources:
https://www.brooklynmuseum.org/eascfa/dinner_party/heritage_floor/kubaba