U:
- Ub Iwerks, the real mastermind behind the world's most beloved Mouse
- Ulrika Stalhammar, Soldier in the Great Northern War
- Urraca of Zamora, Infanta of Zamora
- Ursula Burns, former CEO of Xerox
V:
- Valentina Tereshkova, the first woman to go to space
- Valeria Messalina, Roman Empress
- Varina Davis, The First Lady of the Confederate States of America
- Vera Rubin, Astronomer
- Veronica Franco, Poet and Courtesan
- Vesna Vulovic, Record Holder for Highest Freefall Without a Parachute
- Vibia Sabina, Roman Empress
- Victoria, Need I Type More?
- Victoria Woodhull, The First Woman in US History to Run For President
- Viola Davis, Actress
- Violet Hilton, Conjoined Twin & Vaudeville Performer
- Violet Jessop, Arguably the Luckiest Stewardess Ever
- Violette Szabo, Allied Spy During World War II
- Virginia Dare, the first English baby born in the New World
- Virginia Hall, Allied Spy in World War II
- Vivian (Bullwinkel) Statham, The Only Survivor of the Bangka Survivor Massacre
- Vivian Liberto Distin, Johnny Cash's First Wife
- Vivienne Nearing, Game Show Contestant Convicted of Perjury
W:
- Wade Watts, The Man Who Defined Forgiveness
- Wallace Hartley, The Band Leader aboard the RMS Titanic
- Wallis Simpson, a king left his throne for her
- Walter Hunt, seriously, what didn't this guy invent?
- Walter Knott, the creator of Knott's Berry Farm themepark
- Wang Cong'er, leader of the White Lotus Society and warrior
- Wang Zhenyi, Astronomer and Author
- Watkuese, she was lost and then found again
- Weetamoo, Sunksqua of the Pocasset Wampanoag People
- Corporal Werner Dreschler, German Prisoner of War who was murdered at the Papago Park POW Camp in Arizona
- Whang-od Oggay, The World's Oldest Tattoo Artist
- Whitney Houston, Musician
- Wilford Willy, He died alongside Joe Kennedy Jr
- Wilhelm Krützfeld, the New Synagogue Thanks you
- Willem Arondeus, Gay, resistance fighter, artist, need I say more?
- William Alden Smith, the US Senator who oversaw the RMS Titanic Senate Inquiry into the disaster
- William Carter, RMS Titanic Survivor
- William Cody, otherwise known as Buffalo Bill
- William Coutts Jr, RMS Titanic Survivor
- William Ellison, Well there went the narrative
- William Moulton Marston, original creator of Wonder Woman
- William Petrie, Egyptologist and expert on Bog Bodies
- William L Rathje, his life's work was called The Garbage Project--yes really
- Williamina Paton Stevens Fleming, She Literally Helped "Rewrite the Stars"
- Willie Mallory, Protective Mother and Figure in the Fight Against Eugenics
- Wilma Mankiller, Former Principal Chief of the Cherokee Nation
- Captain Witold Pilecki, volunteered to become a prisoner in Auschwitz
- Wu Zetian, China's only Empress Regnant