S:
- Sacagawea, Savior of the Corps of Discovery
- Sacheen Littlefeather, "Native American" Activist
- Sada Abe, Geisha Who Murdered Her Lover
- Sadako Sasaki, The Real Girl Behind Sadako And the Thousand Paper Cranes
- Safia Farkash El Hadad, Former First Lady of Libya
- Safra Catz, co-CEO of Oracle--and so much more
- Sajida Talfah, First Wife of Saddam Hussein
- Salima Ikram, got a question on Egyptian mummies? Ask her!
- Sally Hemings, Thomas Jefferson's Secret No Longer
- Sally McCoy, The Matriarch of the McCoy Clan
- Sally Ride, the first American Woman to go to space
- Samantha Geimer, Child Rape Survivor
- Samira Shahbandar, Saddam Hussein's Second Wife
- Sammu-Ramat, Empress Regnant of Assyria
- Samuel Scott, RMS Titanic's First Victim
- Santa Inocencia, Mexican Child Saint and Corpse Relic
- Sappho, Famed Greek Poet
- Sara Blakely, Founder of Spanx
- Sarah Anzick, Molecular Biologist
- Sarah Bowman, Camp Follower During the Mexican/American War
- Sarah Bush Lincoln, Abraham Lincoln's Beloved Stepmother
- Private Sarah Edmonds, Union Soldier during the War Between the States
- Sarah Lincoln Grigsby, Abraham Lincoln's Beloved Sister
- Sarah T Hughes, Federal Judge who Delivered the Oath of Office to President LBJ
- Sarah Morgan Dawson, Author of a Confederate Girl's Diary
- Sarah Palin, Politician and Reality TV Star
- Sarah Parcak, she makes satellite technology cool
- Sarah Polk, Former First Lady of the United States
- Sarah Shelton Henry, First Wife of Patrick Henry
- Sarah Thomas, The First Woman to Officiate Multiple NFL Games
- Sarah Winchester, Folk Figure and Heiress to the Winchester Fortune
- Sarah Winnemucca Hopkins, Northern Paiute Activist
- Sau Lan Wu, Particle Physicist
- Major Scott Smiley, he continued to serve after being blinded by a suicide car bomber
- Selena Quintanilla-Perez, Musician
- Selma Lagerlof, The First Woman to be Awarded the Nobel Prize in Literature
- Seraph Young Ford, the First Woman to Cast a Ballot in a US Election
- Serena Shim, Journalist who Dared Report the Truth
- Setepenre, Egyptian Royal Princess
- Seth McKee, he was the highest ranking survivor of D-Day at the time of his death
- Shajar al-Durr, Female Sultan
- Shangguan Wan'er, the first female Prime Minister in history
- Sharbat Gula, Photography Subject Known as the Afghan Girl
- Sharon Tate, Actress and Murder Victim
- Sheila Abdus-Salaam, Associate Judge for the New York Court of Appeals
- Sheri McCoy, she mixes science and business for wondrous results
- Sherry Lansing, first woman to head a major Hollywood Studio
- Shirley Ann Jackson, Physicist
- Shirley Chisholm, The First African American Woman to Serve in the United States House of Representatives
- Shirley Temple, Actress and Diplomat
- Sigourney Weaver, Actress
- Lieutenant Simo Häyhä, possibly the deadliest sniper in world history
- Simon Wiesenthal, the Nazi Hunter
- Simone Veil, Politician and Women's Rights Advocate
- Sirimavo Bandaranaike, Ceylon's First Female Prime Minister
- Smokey Bear, The Real Bear Behind the US's Longest Running PSA
- Sobekneferu, the first definitively proven woman to have ruled Egypt as Pharaoh
- Sofia Kovalevskaya, Pioneering Mathematician
- Sonia Gandhi, Former President of the Indian National Congress (Party)
- Sophia Dorothea of Celle, She Should Have Been Queen of Great Britain and Ireland
- Sophia Hayden, The First Female Graduate of MIT's Architectural Program
- Sophie Blanchard, The First Professional Female Balloonist
- Sophie Scholl, Member of the White Rose Resistance Movement
- Soraya Tarzi, Queen Consort of Afghanistan
- Sparethra, Queen Who Fought Cyrus the Great
- Stand Watie, what was it about that political narrative again?
- Stanislawa Leszczysnka, the Midwife of Auschwitz
- Stefani Germanotta, aka Lady Gaga
- Stella Walsh, Olympic Track and Field Athlete
- Stephanie Freed, Co-Founder and CEO of Rapha House International
- Stephanie of Monaco, Princess and Singer
- Stephanie Murphy, Member of the US House of Representatives
- Stephanie von Hohenlohe, The Princess who was a Nazi Spy
- Steve Buscemi, more than an actor
- Steve Irwin, The Crocodile Hunter
- Father Suitbert Mollinger, he collected over 5,000 Catholic Relics in his church
- Sumiko Iwamuro, Japan's DJ Grandma
- Dr. Susan Anderson, One of the First Female Doctors in Colorado
- Susan B Anthony, Women's Suffrage Advocate
- Susan Boyle, Singer and International Sensation
- Susan La Flesche Picotte, The First Native American Woman to Earn a Medical Degree
- Susan Wojcicki, CEO of YouTube
- Susanna Salter, The First Elected Female Mayor in the United States
- Sushma Swaraj, Former Minister of India's Internal Affairs
- Susie King Taylor, the First African American Army Nurse in United States History
- Sybilla Masters, The First Person in the American Colonies to be Granted an English Patent
- Sylvan Goldman, the inventor of the shopping cart
- Sergeant Sylvester Antolak, Medal of Honor recipient from World War II
- Sue Ellen Cooper, Founder of the Red Hat Society
- Susette La Flesche Tibbles, Author and Activist for Native American Rights
- Sutematsu Oyama, Japanese Women's Education Advocate
- Sybil Ludington, The Real Midnight Rider
- Sylvia Earle, Marine Biologist
T:
- T. E. Lawrence, Lawrence of Arabia
- Tamar, King of Georgia
- "Princess" Tarakanova, Pretender to the Russian Throne
- Tardar Sauce, The Real Kitty Known as "Grumpy Cat"
- Tatiana Nikolaevna Romanova, Grand Duchess of Russia
- Tatiana Proskouriakoff, she was instrumental in the decoding of Maya Hieroglyphs
- Tatyana McFadden, Wheelchair Racer
- Tawosret, Final Pharaoh of Egypt's 19th Dynasty
- Taytu Betul, Empress of Ethiopia
- Te Ata Fisher, Storyteller of the Chickasaw Nation
- Te Puea Herangi, Maori Leader and Activist
- Terra Jole, Actress
- Tessy Thomas, Missile Engineer
- Teuta of Illyria, Queen Regent of the Ardiaei Tribe and a Naval Threat to Rome
- Thea Christiansen Foss, Founder of Foss Maritime, The Largest Tugboat Company in the Western United States
- Theodora I, Byzantine Empress
- Theodora III, Byzantine Empress
- Theodore Roosevelt Jr, even more bada** than his father
- Theresa May, Former Prime Minister of the United Kingdom
- Thích Quảng Đức, the monk who committed self-immolation
- Thomas W Bennett, Conscientious Objector and Medal of Honor Recipient
- Thomas Willard Ray, the only airman killed in the Bay of Pigs to have his body returned home
- Thomasine Cooper White, Stop Calling Her the Butcher!!
- Tiffany Trump, Law Student & Socialite
- Timothy O'Sullivan, A Picture is Worth a Thousand Words
- Tina Turner, Singer and Dancer
- Tituba, Accused of Being a Witch at Salem
- Tiye, Egyptian Queen and Matriarch
- Toby Riddle, Interpreter During the Modoc War
- Togo the Siberian Husky, Sled Dog who Also Helped Deliver Medicine to Children
- Tom Sawyer, no not that Tom Saywer
- Tomoe Gozen, Samurai Warrior
- Toni Basil, Choreographer and More
- Toni Palermo, All-American Girls Professional Baseball League Player
- Topsy the Elephant, Circus Performer
- Toregene Khatun, Ruler of the Mongol Empire for Five Years
- Trakr the Dog, Recovered the Last Survivor of the 9/11 Terror Attacks in New York
- Trevor Habberstad, Stunt Coordinator whose brief life will never be forgotten
- Lady Trieu, Vietnamese Rebel Leader Who Fought the Chinese
- Tripp Phillips, founder of Le-Glue
- Trisha Prabhu, Computer Code Writer Who Appeared on Shark Tank
- Truganini, The Last Full Blooded Aboriginal Tasmanian
- Trung Nhi, she and her sister led a large scale rebellion against their Chinese overlords
- Trung Trac, she and her sister led a large scale rebellion against their Chinese overlords
- Tsai Ing-Wen, President of the Republic of China (Taiwan)
- Tsutomu Yamaguchi, is it really luck that he survived both Hiroshima and Nagasaki?
- Tu Youyou, Pharmaceutical Chemist
- Turhan Hatice Sultan, Regent of the Ottoman Empire
- Tuvia Bielski, Daniel Craig plays him in the movie
- Tye Leung Schulze, Interpreter, Advocate, and So Much More for the Chinese Community
- Tyke the Elephant, Circus Performer
- Tyra Banks, You Better Smize for Me!