452: Nebet
Birth and Death Dates Unknown; 6th Dynasty Egypt
Her husband was Khui and her daughters would marry Pepi I—their names were Akhensenpepi I and II.
Pepi I was one of the most powerful and influential Pharaohs of his time and Nebet oversaw the building of his pyramid and other projects.
Her name connects her to the Egyptian Gods Thoth, Geb, and Horus.
She may have been a princess related to the royal family somehow.
Nebet is the first recorded female vizier in Egyptian history with the next being in the 26th Dynasty. The vizier was the second most powerful person in the Egyptian Empire and was responsible for the day to day activities of keeping the country running smoothly.
Sources:
https://www.ancient-egypt-online.com/ancient-egypt-vizier.html